NXN Antibody, FITC conjugated (PACO62153)
- SKU:
- PACO62153
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | NXN Antibody, FITC conjugated (PACO62153) |
抗体コード: | PACO62153 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Nucleoredoxin protein (155-435AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR (KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity). |
シノニム: | Nucleoredoxin (EC 1.8.1.8), NXN, NRX |
UniProt Protein Function: | NXN: Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A). Belongs to the nucleoredoxin family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 1.8.1.8; Oxidoreductase Chromosomal Location of Human Ortholog: 17p13.3 Biological Process: negative regulation of protein ubiquitination; negative regulation of Wnt receptor signaling pathway |
NCBI Summary: | This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. [provided by RefSeq, Sep 2015] |
UniProt Code: | Q6DKJ4 |
NCBI GenInfo Identifier: | 187471109 |
NCBI Gene ID: | 64359 |
NCBI Accession: | Q6DKJ4.2 |
UniProt Secondary Accession: | Q6DKJ4,Q3SWW6, Q6P3U6, Q7L4C6, Q9H9Q1, B4DXQ0, D3DTH2 |
UniProt Related Accession: | Q6DKJ4 |
Molecular Weight: | 36,871 Da |
NCBI Full Name: | Nucleoredoxin |
NCBI Synonym Full Names: | nucleoredoxin |
NCBI Official Symbol: | NXN |
NCBI Official Synonym Symbols: | NRX; TRG-4 |
NCBI Protein Information: | nucleoredoxin |
UniProt Protein Name: | Nucleoredoxin |
Protein Family: | Nucleoredoxin |
UniProt Gene Name: | NXN |
UniProt Entry Name: | NXN_HUMAN |