NUPR1 Antibody, Biotin conjugated (PACO50445)
- SKU:
- PACO50445
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | NUPR1 Antibody, Biotin conjugated (PACO50445) |
抗体コード: | PACO50445 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Nuclear protein 1 protein (2-64AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 'Lys-16' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin. |
シノニム: | Nuclear protein 1 (Candidate of metastasis 1) (Nuclear transcriptional regulator protein 1) (Protein p8), NUPR1, COM1 |
UniProt Protein Function: | NUPR1: Could participate in the response to proapoptotic stimuli and promotes cellular growth in a way that helps the tissue counteract diverse injuries. May contribute to the metastatic phenotype. Belongs to the NUPR family. |
UniProt Protein Details: | Protein type:Cell development/differentiation; Cell cycle regulation; Apoptosis Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: cytoplasm; nucleus Molecular Function:chromatin binding; DNA binding Biological Process: acute inflammatory response; cell growth; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; male gonad development; negative regulation of cell cycle; negative regulation of fibroblast proliferation; positive regulation of apoptosis; positive regulation of protein modification process; protein amino acid acetylation; protein complex assembly; regulation of transcription from RNA polymerase II promoter; response to toxin; transcription, DNA-dependent |
UniProt Code: | O60356 |
NCBI GenInfo Identifier: | 109948307 |
NCBI Gene ID: | 26471 |
NCBI Accession: | NP_001035948.1 |
UniProt Secondary Accession: | O60356,O60357, Q6FGG3, B2R5C4, |
UniProt Related Accession: | O60356 |
Molecular Weight: | |
NCBI Full Name: | nuclear protein 1 isoform a |
NCBI Synonym Full Names: | nuclear protein 1, transcriptional regulator |
NCBI Official Symbol: | NUPR1 |
NCBI Official Synonym Symbols: | P8; COM1 |
NCBI Protein Information: | nuclear protein 1 |
UniProt Protein Name: | Nuclear protein 1 |
UniProt Synonym Protein Names: | Candidate of metastasis 1; Nuclear transcriptional regulator protein 1 |
Protein Family: | Nuclear protein |
UniProt Gene Name: | NUPR1 |
UniProt Entry Name: | NUPR1_HUMAN |