NUP50 Antibody (PACO16803)
- SKU:
- PACO16803
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | NUP50 Antibody (PACO16803) |
抗体コード: | PACO16803 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
反応性: | Human |
免疫原: | Fusion protein of human NUP50 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hela cells, 293T cells, A549 cells, HT29 cells, Primary antibody: PACO16803(NUP50 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16803(NUP50 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the Cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene. |
シノニム: | nucleoporin 50kDa |
UniProt Protein Function: | NUP50: Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin- alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nuclear import; Nucleoporin Chromosomal Location of Human Ortholog: 22q13.31 Cellular Component: cytoplasm; nuclear membrane; nucleoplasm Molecular Function:protein binding; Ran GTPase binding Biological Process: mitotic nuclear envelope disassembly; mRNA export from nucleus; protein import into nucleus; protein sumoylation; RNA-mediated gene silencing; tRNA export from nucleus; viral reproduction; viral transcription |
NCBI Summary: | The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UKX7 |
NCBI GenInfo Identifier: | 20455193 |
NCBI Gene ID: | 10762 |
NCBI Accession: | Q9UKX7.2 |
UniProt Secondary Accession: | Q9UKX7,O75644, Q8N6V5, Q9NPM9, Q9NPR6, Q9P1K5, B1AHA4 B2RB15, |
UniProt Related Accession: | Q9UKX7 |
Molecular Weight: | 46,863 Da |
NCBI Full Name: | Nuclear pore complex protein Nup50 |
NCBI Synonym Full Names: | nucleoporin 50 |
NCBI Official Symbol: | NUP50 |
NCBI Official Synonym Symbols: | NPAP60; NPAP60L |
NCBI Protein Information: | nuclear pore complex protein Nup50 |
UniProt Protein Name: | Nuclear pore complex protein Nup50 |
UniProt Synonym Protein Names: | 50 kDa nucleoporin; Nuclear pore-associated protein 60 kDa-like; Nucleoporin Nup50 |
Protein Family: | Nuclear pore complex protein |
UniProt Gene Name: | NUP50 |
UniProt Entry Name: | NUP50_HUMAN |