NUDT5 Antibody, HRP conjugated (PACO58597)
- SKU:
- PACO58597
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | NUDT5 Antibody, HRP conjugated (PACO58597) |
抗体コード: | PACO58597 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human ADP-sugar pyrophosphatase protein (34-166AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). |
シノニム: | ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H), NUDT5, NUDIX5 |
UniProt Protein Function: | NUDT5: Hydrolyzes with similar activities ADP-ribose ADP- mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Belongs to the Nudix hydrolase family. |
UniProt Protein Details: | Protein type:EC 3.6.1.13; EC 3.6.1.58; Nucleotide Metabolism - purine; Phosphatase Chromosomal Location of Human Ortholog: 10p14 Cellular Component: cytosol; nucleus Molecular Function:ADP-ribose diphosphatase activity; ADP-sugar diphosphatase activity; m7G(5')pppN diphosphatase activity; magnesium ion binding; nucleotidyltransferase activity; protein binding; protein homodimerization activity; snoRNA binding Biological Process: chromatin remodeling; D-ribose catabolic process; ribonucleoside diphosphate catabolic process |
NCBI Summary: | This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013] |
UniProt Code: | Q9UKK9 |
NCBI GenInfo Identifier: | 20455192 |
NCBI Gene ID: | 11164 |
NCBI Accession: | Q9UKK9.1 |
UniProt Secondary Accession: | Q9UKK9,Q6IAG0, Q9UH49, A8K516, |
UniProt Related Accession: | Q9UKK9 |
Molecular Weight: | 24kDa |
NCBI Full Name: | ADP-sugar pyrophosphatase |
NCBI Synonym Full Names: | nudix hydrolase 5 |
NCBI Official Symbol: | NUDT5 |
NCBI Official Synonym Symbols: | YSA1; YSA1H; YSAH1; hNUDT5 |
NCBI Protein Information: | ADP-sugar pyrophosphatase |
UniProt Protein Name: | ADP-sugar pyrophosphatase |
UniProt Synonym Protein Names: | 8-oxo-dGDP phosphatase (EC:3.6.1.58 |
Protein Family: | Nudix hydrolase |
UniProt Gene Name: | NUDT5 |