NTHL1 Antibody, HRP conjugated (PACO53707)
- SKU:
- PACO53707
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | NTHL1 Antibody, HRP conjugated (PACO53707) |
抗体コード: | PACO53707 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Endonuclease III-like protein 1 protein (31-312AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption. |
シノニム: | Endonuclease III-like protein 1 (hNTH1) (EC 3.2.2) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase), NTHL1, NTH1 OCTS3 |
UniProt Protein Function: | NTHL1: Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site. Required for the repair of both oxidative DNA damage and spontaneous mutagenic lesions. Belongs to the Nth/MutY family. |
UniProt Protein Details: | Protein type:DNA repair, damage; Mitochondrial; Lyase; EC 4.2.99.18; Hydrolase Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: mitochondrion; nucleoplasm; nucleus Molecular Function:4 iron, 4 sulfur cluster binding; DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) lyase activity; double-stranded DNA binding; endonuclease activity; metal ion binding; oxidized purine base lesion DNA N-glycosylase activity; oxidized pyrimidine base lesion DNA N-glycosylase activity; protein binding Biological Process: base-excision repair, AP site formation; depyrimidination; nucleotide-excision repair, DNA incision, 5'-to lesion; positive regulation of defense response to virus by host Disease: Familial Adenomatous Polyposis 3 |
NCBI Summary: | The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq, Oct 2008] |
UniProt Code: | P78549 |
NCBI GenInfo Identifier: | 29840795 |
NCBI Gene ID: | 4913 |
NCBI Accession: | P78549.2 |
UniProt Secondary Accession: | P78549,Q1MVR1, Q99566, Q99794, Q9BPX2, |
UniProt Related Accession: | P78549 |
Molecular Weight: | 32,839 Da |
NCBI Full Name: | Endonuclease III-like protein 1 |
NCBI Synonym Full Names: | nth-like DNA glycosylase 1 |
NCBI Official Symbol: | NTHL1 |
NCBI Official Synonym Symbols: | FAP3; NTH1; OCTS3; hNTH1 |
NCBI Protein Information: | endonuclease III-like protein 1 |
UniProt Protein Name: | Endonuclease III-like protein 1 |
UniProt Synonym Protein Names: | Bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase |
Protein Family: | Neutral trehalase |
UniProt Gene Name: | NTHL1 |
UniProt Entry Name: | NTH_HUMAN |