NRG4 Antibody, Biotin conjugated (PACO64346)
- SKU:
- PACO64346
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | NRG4 Antibody, Biotin conjugated (PACO64346) |
抗体コード: | PACO64346 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Pro-neuregulin-4, membrane-bound isoform protein (1-115AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity). |
シノニム: | Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Cleaved into: Neuregulin-4 (NRG-4)], NRG4 |
UniProt Protein Function: | NRG4: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. Belongs to the neuregulin family. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 15q24.2 Cellular Component: extracellular space; integral to membrane; extracellular region; plasma membrane Molecular Function:growth factor activity; receptor binding Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; organ development; innate immune response |
NCBI Summary: | The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q8WWG1 |
NCBI GenInfo Identifier: | 28201832 |
NCBI Gene ID: | 145957 |
NCBI Accession: | Q8WWG1.1 |
UniProt Secondary Accession: | Q8WWG1,A6NIE8, |
UniProt Related Accession: | Q8WWG1 |
Molecular Weight: | |
NCBI Full Name: | Pro-neuregulin-4, membrane-bound isoform |
NCBI Synonym Full Names: | neuregulin 4 |
NCBI Official Symbol: | NRG4 |
NCBI Official Synonym Symbols: | HRG4 |
NCBI Protein Information: | pro-neuregulin-4, membrane-bound isoform; pro-NRG4; heregulin 4 |
UniProt Protein Name: | Pro-neuregulin-4, membrane-bound isoform |
Protein Family: | Pro-neuregulin |
UniProt Gene Name: | NRG4 |
UniProt Entry Name: | NRG4_HUMAN |