NRCAM Antibody, HRP conjugated (PACO57901)
- SKU:
- PACO57901
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | NRCAM Antibody, HRP conjugated (PACO57901) |
抗体コード: | PACO57901 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Neuronal cell adhesion molecule protein (1194-1299AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. |
シノニム: | Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (hBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related), NRCAM, KIAA0343 |
UniProt Protein Function: | NRCAM: Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier. Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. 5 isoforms of the human protein are produced by alternative splicing.Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 7q31Cellular Component: plasma membraneMolecular Function: ankyrin binding; protein bindingBiological Process: angiogenesis; clustering of voltage-gated sodium channels; synaptogenesis |
UniProt Protein Details: | |
NCBI Summary: | Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q92823 |
NCBI GenInfo Identifier: | 215274127 |
NCBI Gene ID: | 4897 |
NCBI Accession: | Q92823.3 |
UniProt Secondary Accession: | Q92823,O15051, O15179, Q14BM2, Q9UHI3, Q9UHI4, A4D0S3 E9PDA4 |
UniProt Related Accession: | Q92823 |
Molecular Weight: | 131,744 Da |
NCBI Full Name: | Neuronal cell adhesion molecule |
NCBI Synonym Full Names: | neuronal cell adhesion molecule |
NCBI Official Symbol: | NRCAM |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | neuronal cell adhesion molecule |
UniProt Protein Name: | Neuronal cell adhesion molecule |
UniProt Synonym Protein Names: | Neuronal surface protein Bravo |
Protein Family: | Neuronal cell adhesion molecule |
UniProt Gene Name: | NRCAM |
UniProt Entry Name: | NRCAM_HUMAN |