NPRL2 Antibody (PACO43094)
- SKU:
- PACO43094
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | NPRL2 Antibody (PACO43094) |
抗体コード: | PACO43094 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Nitrogen permease regulator 2-like protein (1-220AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: Nitrogen permease regulator 2-like protein antibody at 7µg/ml + Mouse skeletal muscle tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 44, 24 kDa. Observed band size: 44 kDa. |
![]() | Immunohistochemistry of paraffin-embedded human lung cancer using PACO43094 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human colon tissue using PACO43094 at dilution of 1:100. |
バックグラウンド: | Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs. As a component of the GATOR1 complex, inhibitor of the amino acid, sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. |
シノニム: | GATOR complex protein NPRL2 (Gene 21 protein) (G21 protein) (Nitrogen permease regulator 2-like protein) (NPR2-like protein) (Tumor suppressor candidate 4), NPRL2, TUSC4 |
UniProt Protein Function: | NPRL2: Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs. Belongs to the NPR2 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Tumor suppressor; Inhibitor Chromosomal Location of Human Ortholog: 3p21.3 Molecular Function:protein binding; GTPase activator activity; protein kinase activity Biological Process: negative regulation of kinase activity; protein amino acid phosphorylation; positive regulation of GTPase activity |
UniProt Code: | Q8WTW4 |
NCBI GenInfo Identifier: | 47117604 |
NCBI Gene ID: | 10641 |
NCBI Accession: | Q8WTW4.2 |
UniProt Secondary Accession: | Q8WTW4,Q6FGS2, Q9Y249, Q9Y497, A8K831, |
UniProt Related Accession: | Q8WTW4 |
Molecular Weight: | Observed MW 40kDaCalculated MW 23kDa/43kDa |
NCBI Full Name: | Nitrogen permease regulator 2-like protein |
NCBI Synonym Full Names: | nitrogen permease regulator-like 2 (S. cerevisiae) |
NCBI Official Symbol: | NPRL2 |
NCBI Official Synonym Symbols: | NPR2; NPR2L; TUSC4 |
NCBI Protein Information: | nitrogen permease regulator 2-like protein; G21 protein; 2810446G01Rik; gene 21 protein; NPR2-like protein; tumor suppressor candidate 4; homologous to yeast nitrogen permease (candidate tumor suppressor) |
UniProt Protein Name: | Nitrogen permease regulator 2-like protein |
UniProt Synonym Protein Names: | Gene 21 protein; G21 protein; Tumor suppressor candidate 4 |
Protein Family: | Nitrogen permease regulator 2-like protein |
UniProt Gene Name: | NPRL2 |
UniProt Entry Name: | NPRL2_HUMAN |