NPPC Antibody (PACO18773)
- SKU:
- PACO18773
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | NPPC Antibody (PACO18773) |
抗体コード: | PACO18773 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthetic peptide of human NPPC |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO18773(NPPC Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined. |
シノニム: | Notch 4 |
UniProt Protein Function: | NPPC: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3. Belongs to the natriuretic peptide family. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Hormone; Secreted Chromosomal Location of Human Ortholog: 2q37.1 Cellular Component: extracellular region Molecular Function:receptor binding Biological Process: cGMP biosynthetic process; negative regulation of meiotic cell cycle; receptor guanylyl cyclase signaling pathway; regulation of cAMP metabolic process; regulation of cGMP metabolic process |
NCBI Summary: | This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015] |
UniProt Code: | P23582 |
NCBI GenInfo Identifier: | 113850 |
NCBI Gene ID: | 4880 |
NCBI Accession: | P23582.1 |
UniProt Secondary Accession: | P23582,Q4ZG41, |
UniProt Related Accession: | P23582 |
Molecular Weight: | 13,246 Da |
NCBI Full Name: | C-type natriuretic peptide |
NCBI Synonym Full Names: | natriuretic peptide C |
NCBI Official Symbol: | NPPC |
NCBI Official Synonym Symbols: | CNP; CNP2 |
NCBI Protein Information: | C-type natriuretic peptide |
UniProt Protein Name: | C-type natriuretic peptide |
Protein Family: | C-type natriuretic peptide |
UniProt Gene Name: | NPPC |
UniProt Entry Name: | ANFC_HUMAN |