NLRP7 Antibody, HRP conjugated (PACO57353)
- SKU:
- PACO57353
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | NLRP7 Antibody, HRP conjugated (PACO57353) |
抗体コード: | PACO57353 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human NACHT, LRR and PYD domains-containing protein 7 protein (89-187AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Inhibits CASP1/caspase-1-dependent IL1B secretion. |
シノニム: | NACHT, LRR and PYD domains-containing protein 7 (Nucleotide-binding oligomerization domain protein 12) (PYRIN-containing APAF1-like protein 3), NLRP7, NALP7 NOD12 PYPAF3 |
UniProt Protein Function: | NLRP7: Inhibits CASP1/caspase-1-dependent IL1B secretion. Defects in NLRP7 are the cause of hydatidiform mole recurrent type 1 (HYDM1). A disorder characterized by excessive trophoblast development and the presence of a growing mass of tissue inside the uterus at the beginning of a pregnancy. It leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi. Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Apoptosis Chromosomal Location of Human Ortholog: 19q13.42 Disease: Hydatidiform Mole, Recurrent, 1 |
NCBI Summary: | This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8WX94 |
NCBI GenInfo Identifier: | 24212128 |
NCBI Gene ID: | 199713 |
NCBI Accession: | Q8WX94.1 |
UniProt Secondary Accession: | Q8WX94,Q32MH8, Q7RTR1, E9PE16, |
UniProt Related Accession: | Q8WX94 |
Molecular Weight: | 112kDa |
NCBI Full Name: | NACHT, LRR and PYD domains-containing protein 7 |
NCBI Synonym Full Names: | NLR family pyrin domain containing 7 |
NCBI Official Symbol: | NLRP7 |
NCBI Official Synonym Symbols: | HYDM; PAN7; NALP7; NOD12; PYPAF3; CLR19.4 |
NCBI Protein Information: | NACHT, LRR and PYD domains-containing protein 7 |
UniProt Protein Name: | NACHT, LRR and PYD domains-containing protein 7 |
UniProt Synonym Protein Names: | Nucleotide-binding oligomerization domain protein 12; PYRIN-containing APAF1-like protein 3 |
Protein Family: | NACHT, LRR and PYD domains-containing protein |
UniProt Gene Name: | NLRP7 |