バックグラウンド: | As the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP6, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. The precise NLRP6 activation stimulus has not been identified yet (By similarity). Essential for gut mucosal self-renewal and proliferation. Maintains intestinal homeostasis and a healthy intestinal microbiota. This function is, at least partially, mediated by IL18, and not IL1B, produced by nonhematopoietic cells. Influences intestinal barrier function and microbial homeostasis through the regulation of goblet cell mucus secretion. Acts by promoting autophagy in goblet cells, an essential step for mucus granule exocytosis. Its role in goblet cell physiology is inflammasome-dependent, but IL1B- and IL18-independent. During systemic bacterial infections, may negatively regulate inflammatory signaling and inhibit the influx of monocytes and neutrophils to the circulation and to the peritoneum. May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism (By similarity). |
シノニム: | NACHT, LRR and PYD domains-containing protein 6 (Angiotensin II/vasopressin receptor) (PYRIN-containing APAF1-like protein 5), NLRP6, NALP6 PYPAF5 |
UniProt Protein Function: | NLRP6: May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation. Belongs to the NLRP family. |
UniProt Protein Details: | Protein type:Receptor, misc. Chromosomal Location of Human Ortholog: 11p15 Molecular Function:vasopressin receptor activity Biological Process: regulation of inflammatory response |
NCBI Summary: | The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013] |
UniProt Code: | P59044 |
NCBI GenInfo Identifier: | 259016285 |
NCBI Gene ID: | 171389 |
NCBI Accession: | P59044.2 |
UniProt Secondary Accession: | P59044,A8K9F3, E9PJZ8, |
UniProt Related Accession: | P59044 |
Molecular Weight: | 98,681 Da |
NCBI Full Name: | NACHT, LRR and PYD domains-containing protein 6 |
NCBI Synonym Full Names: | NLR family pyrin domain containing 6 |
NCBI Official Symbol: | NLRP6 |
NCBI Official Synonym Symbols: | AVR; NAVR; PAN3; NALP6; PYPAF5; CLR11.4; NAVR/AVR |
NCBI Protein Information: | NACHT, LRR and PYD domains-containing protein 6 |
UniProt Protein Name: | NACHT, LRR and PYD domains-containing protein 6 |
UniProt Synonym Protein Names: | Angiotensin II/vasopressin receptor; PYRIN-containing APAF1-like protein 5 |
Protein Family: | NACHT, LRR and PYD domains-containing protein |
UniProt Gene Name: | NLRP6 |
UniProt Entry Name: | NLRP6_HUMAN |