NLRP2 Antibody (PACO43819)
- SKU:
- PACO43819
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | NLRP2 Antibody (PACO43819) |
抗体コード: | PACO43819 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:200-1:1000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human NACHT, LRR and PYD domains-containing protein 2 protein (1-220AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: NLRP2 antibody at 12µg/ml + A431 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 121, 119, 97, 118 kDa. Observed band size: 121 kDa. | |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO43819 at dilution of 1:100. |
バックグラウンド: | Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. |
シノニム: | NACHT, LRR and PYD domains-containing protein 2 (Nucleotide-binding site protein 1) (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2), NLRP2, NALP2 NBS1 PAN1 PYPAF2 |
UniProt Protein Function: | NLRP2: Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. Belongs to the NLRP family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 19q13.42 Cellular Component: cytoplasm; Golgi apparatus; intracellular membrane-bound organelle; nuclear chromosome, telomeric region Molecular Function:protein binding; Pyrin domain binding Biological Process: positive regulation of caspase activity; positive regulation of interleukin-1 beta secretion |
NCBI Summary: | This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016] |
UniProt Code: | Q9NX02 |
NCBI GenInfo Identifier: | 17380148 |
NCBI Gene ID: | 55655 |
NCBI Accession: | Q9NX02.1 |
UniProt Secondary Accession: | Q9NX02,Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9 Q9NWK3, B4DZL7, I3L0G4, |
UniProt Related Accession: | Q9NX02 |
Molecular Weight: | 117,883 Da |
NCBI Full Name: | NACHT, LRR and PYD domains-containing protein 2 |
NCBI Synonym Full Names: | NLR family pyrin domain containing 2 |
NCBI Official Symbol: | NLRP2 |
NCBI Official Synonym Symbols: | NBS1; PAN1; NALP2; PYPAF2; CLR19.9 |
NCBI Protein Information: | NACHT, LRR and PYD domains-containing protein 2 |
UniProt Protein Name: | NACHT, LRR and PYD domains-containing protein 2 |
UniProt Synonym Protein Names: | Nucleotide-binding site protein 1; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2 |
UniProt Gene Name: | NLRP2 |