NLGN4X Antibody, HRP conjugated (PACO57365)
- SKU:
- PACO57365
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Description
抗体名: | NLGN4X Antibody, HRP conjugated (PACO57365) |
抗体コード: | PACO57365 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Neuroligin-4, X-linked protein (383-494AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Putative neuronal cell surface protein involved in cell-cell-interactions. |
シノニム: | Neuroligin-4, X-linked (Neuroligin X) (HNLX), NLGN4X, KIAA1260 NLGN4 |
UniProt Protein Function: | NLGN4X: Putative neuronal cell surface protein involved in cell- cell-interactions. Defects in NLGN4X may be the cause of susceptibility to autism X-linked type 2 (AUTSX2). AUTSX2 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Defects in NLGN4X may be the cause of susceptibility to X-linked Asperger syndrome 2 (ASPGX2). ASPGX2 is considered to be a form of childhood autism. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: Xp22.33 Cellular Component: postsynaptic membrane; extracellular space; cell surface; integral to plasma membrane; postsynaptic density; dendrite; integral to membrane; plasma membrane; excitatory synapse; synapse; cell junction Molecular Function:protein binding; protein homodimerization activity; neurexin binding; cell adhesion molecule binding; receptor activity; chloride ion binding Biological Process: neuron differentiation; regulation of synaptic transmission; organ growth; intercellular junction assembly and maintenance; metabolic process; adult behavior; synapse organization and biogenesis; cerebellum development; neuron adhesion; social behavior; learning Disease: Asperger Syndrome, X-linked, Susceptibility To, 2; Autism, Susceptibility To, X-linked 2 |
NCBI Summary: | This gene encodes a member of the type-B carboxylesterase/lipase protein family. The encoded protein belongs to a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs large homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
UniProt Code: | Q8N0W4 |
NCBI GenInfo Identifier: | 31076821 |
NCBI Gene ID: | 57502 |
NCBI Accession: | Q8N0W4.1 |
UniProt Secondary Accession: | Q8N0W4,Q6UX10, Q9ULG0, |
UniProt Related Accession: | Q8N0W4 |
Molecular Weight: | 91,915 Da |
NCBI Full Name: | Neuroligin-4, X-linked |
NCBI Synonym Full Names: | neuroligin 4, X-linked |
NCBI Official Symbol: | NLGN4X |
NCBI Official Synonym Symbols: | HLNX; HNL4X; NLGN4; ASPGX2; AUTSX2 |
NCBI Protein Information: | neuroligin-4, X-linked |
UniProt Protein Name: | Neuroligin-4, X-linked |
UniProt Synonym Protein Names: | HNLX |
Protein Family: | Neuroligin |
UniProt Gene Name: | NLGN4X |
UniProt Entry Name: | NLGNX_HUMAN |