NHEJ1 Antibody (PACO51090)
- SKU:
- PACO51090
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | NHEJ1 Antibody (PACO51090) |
抗体コード: | PACO51090 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Non-homologous end-joining factor 1 protein (225-296AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunofluorescent analysis of Hela cells using PACO51090 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary. Binds DNA in a length-dependent manner. |
シノニム: | Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor), NHEJ1, XLF |
UniProt Protein Function: | NHEJ1: DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary. Interacts with XRCC4 and the XRCC4-LIG4 complex. Binds DNA in a length-dependent manner. Ubiquitously expressed. Belongs to the XLF family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA repair, damage Chromosomal Location of Human Ortholog: 2q35 Cellular Component: nucleus Molecular Function:protein binding; DNA binding Biological Process: central nervous system development; B cell differentiation; response to ionizing radiation; positive regulation of ligase activity; double-strand break repair via nonhomologous end joining; DNA recombination; T cell differentiation Disease: Severe Combined Immunodeficiency With Microcephaly, Growth Retardation, And Sensitivity To Ionizing Radiation |
NCBI Summary: | Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9H9Q4 |
NCBI GenInfo Identifier: | 74734059 |
NCBI Gene ID: | 79840 |
NCBI Accession: | Q9H9Q4.1 |
UniProt Secondary Accession: | Q9H9Q4,Q4ZFW7, Q6IA64, Q96JS9, B8ZZA4, |
UniProt Related Accession: | Q9H9Q4 |
Molecular Weight: | 299 |
NCBI Full Name: | Non-homologous end-joining factor 1 |
NCBI Synonym Full Names: | nonhomologous end-joining factor 1 |
NCBI Official Symbol: | NHEJ1 |
NCBI Official Synonym Symbols: | XLF |
NCBI Protein Information: | non-homologous end-joining factor 1; XRCC4-like factor; protein cernunnos |
UniProt Protein Name: | Non-homologous end-joining factor 1 |
UniProt Synonym Protein Names: | Protein cernunnos; XRCC4-like factor |
Protein Family: | Non-homologous end-joining factor |
UniProt Gene Name: | NHEJ1 |
UniProt Entry Name: | NHEJ1_HUMAN |
Antibodies |
Anti-NHEJ1 Antibody (CAB4985) |
Anti-NHEJ1 Antibody (CAB19957)[KO Validated] |
NHEJ1 Antibody (PACO10848) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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