NFKBIL1 Antibody (PACO59497)
- SKU:
- PACO59497
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | NFKBIL1 Antibody (PACO59497) |
抗体コード: | PACO59497 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
反応性: | Human |
免疫原: | Recombinant Human NF-kappa-B inhibitor-like protein 1 protein (185-312AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO59497 diluted at 1:600 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. |
シノニム: | NF-kappa-B inhibitor-like protein 1 (Inhibitor of κ B-like protein) (I-kappa-B-like protein) (IkappaBL) (Nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor-like 1), NFKBIL1, IKBL |
UniProt Protein Function: | NFKBIL1: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. Defects in NFKBIL1 are a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription regulation Chromosomal Location of Human Ortholog: 6p21.33 Cellular Component: intermediate filament cytoskeleton; nucleoplasm; nucleus Molecular Function:protein binding Biological Process: cytoplasmic sequestering of transcription factor; I-kappaB kinase/NF-kappaB cascade; inhibition of NF-kappaB transcription factor; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of toll-like receptor signaling pathway; negative regulation of tumor necrosis factor production Disease: Rheumatoid Arthritis |
NCBI Summary: | This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009] |
UniProt Code: | Q9UBC1 |
NCBI GenInfo Identifier: | 44888077 |
NCBI Gene ID: | 4795 |
NCBI Accession: | Q9UBC1.1 |
UniProt Secondary Accession: | Q9UBC1,Q14625, Q5HYU4, Q5RJ72, Q5ST96, Q5STV4, Q5STV5 Q9UBX4, A6NL91, B4DUW1, |
UniProt Related Accession: | Q9UBC1 |
Molecular Weight: | 41,368 Da |
NCBI Full Name: | NF-kappa-B inhibitor-like protein 1 |
NCBI Synonym Full Names: | NFKB inhibitor like 1 |
NCBI Official Symbol: | NFKBIL1 |
NCBI Official Synonym Symbols: | IKBL; LST1; NFKBIL |
NCBI Protein Information: | NF-kappa-B inhibitor-like protein 1 |
UniProt Protein Name: | NF-kappa-B inhibitor-like protein 1 |
UniProt Synonym Protein Names: | Inhibitor of kappa B-like protein; I-kappa-B-like protein; IkappaBL; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 |
Protein Family: | NF-kappa-B inhibitor-like protein |
UniProt Gene Name: | NFKBIL1 |
Antibodies |
Anti-NFKBIL-1 Antibody (CAB10456) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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