NFKBIE Antibody (PACO45550)
- SKU:
- PACO45550
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | NFKBIE Antibody (PACO45550) |
抗体コード: | PACO45550 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human NF-kappa-B inhibitor epsilon protein (140-280AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO45550 at dilution of 1:100. |
バックグラウンド: | Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. |
シノニム: | NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon), NFKBIE, IKBE |
UniProt Protein Function: | IkB-epsilon: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit. Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages. Belongs to the NF-kappa-B inhibitor family. |
UniProt Protein Details: | Protein type:DNA-binding; Inhibitor Chromosomal Location of Human Ortholog: 6p21.1 Cellular Component: cytoplasm; cytosol Molecular Function:protein binding Biological Process: cytoplasmic sequestering of transcription factor |
NCBI Summary: | The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011] |
UniProt Code: | O00221 |
NCBI GenInfo Identifier: | 206729919 |
NCBI Gene ID: | 4794 |
NCBI Accession: | O00221.3 |
UniProt Secondary Accession: | O00221,Q5T9V9, |
UniProt Related Accession: | O00221 |
Molecular Weight: | 52,864 Da |
NCBI Full Name: | NF-kappa-B inhibitor epsilon |
NCBI Synonym Full Names: | NFKB inhibitor epsilon |
NCBI Official Symbol: | NFKBIE |
NCBI Official Synonym Symbols: | IKBE |
NCBI Protein Information: | NF-kappa-B inhibitor epsilon |
UniProt Protein Name: | NF-kappa-B inhibitor epsilon |
UniProt Synonym Protein Names: | I-kappa-B-epsilon; IkB-E; IkB-epsilon; IkappaBepsilon |
Protein Family: | NF-kappa-B inhibitor |
UniProt Gene Name: | NFKBIE |
UniProt Entry Name: | IKBE_HUMAN |
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