NET1 Antibody (PACO10821)
- SKU:
- PACO10821
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | NET1 Antibody (PACO10821) |
抗体コード: | PACO10821 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human NET1 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | 596aa,68kd; |
UniProt Protein Function: | NET1: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Oncoprotein; GEFs, Rac/Rho; GEFs; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 10p15 Cellular Component: plasma membrane; nucleus; cytosol Molecular Function:Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; GTP-Rho binding Biological Process: regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction; myoblast migration; regulation of cell growth; signal transduction |
NCBI Summary: | This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012] |
UniProt Code: | Q7Z628 |
NCBI GenInfo Identifier: | 52782735 |
NCBI Gene ID: | 10276 |
NCBI Accession: | Q7Z628.1 |
UniProt Secondary Accession: | Q7Z628,Q12773, Q96D82, Q99903, Q9UEN6, |
UniProt Related Accession: | Q7Z628 |
Molecular Weight: | 596 |
NCBI Full Name: | Neuroepithelial cell-transforming gene 1 protein |
NCBI Synonym Full Names: | neuroepithelial cell transforming 1 |
NCBI Official Symbol: | NET1 |
NCBI Official Synonym Symbols: | NET1A; ARHGEF8 |
NCBI Protein Information: | neuroepithelial cell-transforming gene 1 protein; p65 Net1 proto-oncogene protein; small GTP-binding protein regulator; neuroepithelioma transforming gene 1; Rho guanine nucleotide exchange factor (GEF) 8; guanine nucleotide regulatory protein (oncogene) |
UniProt Protein Name: | Neuroepithelial cell-transforming gene 1 protein |
UniProt Synonym Protein Names: | Proto-oncogene p65 Net1; Rho guanine nucleotide exchange factor 8 |
Protein Family: | Nucleolar protein |
UniProt Gene Name: | NET1 |
UniProt Entry Name: | ARHG8_HUMAN |