NEIL1 Antibody (PACO10812)
- SKU:
- PACO10812
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | NEIL1 Antibody (PACO10812) |
抗体コード: | PACO10812 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human NEIL1 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | nei endonuclease VIII-like 1 (E. coli);NEIL1;FLJ22402;FPG1;NEI1;hFPG1 ; |
UniProt Protein Function: | NEIL1: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8- oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Belongs to the FPG family. |
UniProt Protein Details: | Protein type:DNA repair, damage; Hydrolase; EC 4.2.99.18; Lyase Chromosomal Location of Human Ortholog: 15q24.2 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) lyase activity; hydrolase activity, acting on glycosyl bonds; protein C-terminus binding Biological Process: base-excision repair; depyrimidination; negative regulation of nuclease activity; response to oxidative stress |
NCBI Summary: | This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] |
UniProt Code: | Q96FI4 |
NCBI GenInfo Identifier: | 56404654 |
NCBI Gene ID: | 79661 |
NCBI Accession: | Q96FI4.3 |
UniProt Secondary Accession: | Q96FI4,Q6ZRA7, Q86XW7, Q9H6C3, D3DW75, |
UniProt Related Accession: | Q96FI4 |
Molecular Weight: | 43,684 Da |
NCBI Full Name: | Endonuclease 8-like 1 |
NCBI Synonym Full Names: | nei like DNA glycosylase 1 |
NCBI Official Symbol: | NEIL1 |
NCBI Official Synonym Symbols: | FPG1; NEI1; hFPG1 |
NCBI Protein Information: | endonuclease 8-like 1 |
UniProt Protein Name: | Endonuclease 8-like 1 |
UniProt Synonym Protein Names: | DNA glycosylase/AP lyase Neil1; DNA-(apurinic or apyrimidinic site) lyase Neil1; Endonuclease VIII-like 1; FPG1; Nei homolog 1; NEH1; Nei-like protein 1 |
Protein Family: | Endonuclease |
UniProt Gene Name: | NEIL1 |
UniProt Entry Name: | NEIL1_HUMAN |