NEFH Antibody, Biotin conjugated (PACO64330)
- SKU:
- PACO64330
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | NEFH Antibody, Biotin conjugated (PACO64330) |
抗体コード: | PACO64330 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Neurofilament heavy polypeptide protein (825-1003AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins. |
シノニム: | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein), NEFH, KIAA0845 NFH |
UniProt Protein Function: | NFH: Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins. Belongs to the intermediate filament family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 22q12.2 Cellular Component: mitochondrion; axon; cytoplasm; neurofilament Molecular Function:protein binding, bridging; dynein binding; structural constituent of cytoskeleton; kinesin binding; microtubule binding; structural molecule activity; protein kinase binding Biological Process: axonogenesis; neurofilament bundle assembly; microtubule cytoskeleton organization and biogenesis; cell projection biogenesis; peripheral nervous system neuron axonogenesis Disease: Amyotrophic Lateral Sclerosis 1 |
NCBI Summary: | Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008] |
UniProt Code: | P12036 |
NCBI GenInfo Identifier: | 226726294 |
NCBI Gene ID: | 4744 |
NCBI Accession: | P12036.4 |
UniProt Secondary Accession: | P12036,Q96HF8, Q9UJS7, Q9UQ14, B4DYY4, |
UniProt Related Accession: | P12036 |
Molecular Weight: | |
NCBI Full Name: | Neurofilament heavy polypeptide |
NCBI Synonym Full Names: | neurofilament, heavy polypeptide |
NCBI Official Symbol: | NEFH |
NCBI Official Synonym Symbols: | NFH |
NCBI Protein Information: | neurofilament heavy polypeptide; NF-H; 200 kDa neurofilament protein; neurofilament triplet H protein; neurofilament, heavy polypeptide 200kDa |
UniProt Protein Name: | Neurofilament heavy polypeptide |
UniProt Synonym Protein Names: | 200 kDa neurofilament protein; Neurofilament triplet H protein |
Protein Family: | Neurofilament heavy polypeptide |
UniProt Gene Name: | NEFH |
UniProt Entry Name: | NFH_HUMAN |