NDUFA13 Antibody (PACO16445)
- SKU:
- PACO16445
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | NDUFA13 Antibody (PACO16445) |
抗体コード: | PACO16445 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:100-1:300 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human NDUFA13 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16445(NDUFA13 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse skeletal muscle, human hepatocellular carcinoma tissue, Primary antibody: PACO16445(NDUFA13 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO16445(NDUFA13 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined. |
シノニム: | NADH dehydrogenase (ubiquinone) 1 α subcomplex, 13 |
UniProt Protein Function: | GRIM-19: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes. Defects in NDUFA13 may be a cause of susceptibility to Hurthle cell thyroid carcinoma (HCTC). Hurthle cell thyroid carcinoma accounts for approximately 3% of all thyroid cancers. Although they are classified as variants of follicular neoplasms, they are more often multifocal and somewhat more aggressive and are less likely to take up iodine than are other follicular neoplasms. Belongs to the complex I NDUFA13 subunit family. |
UniProt Protein Details: | Protein type:Oxidoreductase; Membrane protein, integral; Mitochondrial Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: nucleoplasm; mitochondrion; mitochondrial membrane; mitochondrial inner membrane; cytoplasm; integral to membrane; mitochondrial respiratory chain; mitochondrial respiratory chain complex I Molecular Function:protein binding; NADH dehydrogenase (ubiquinone) activity; ATP binding; NADH dehydrogenase activity Biological Process: cellular metabolic process; positive regulation of protein catabolic process; positive regulation of caspase activity; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; protein import into mitochondrial inner membrane Disease: Thyroid Carcinoma, Hurthle Cell |
NCBI Summary: | This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined. [provided by RefSeq, Oct 2009] |
UniProt Code: | Q9P0J0 |
NCBI GenInfo Identifier: | 20139242 |
NCBI Gene ID: | 51079 |
NCBI Accession: | Q9P0J0.3 |
UniProt Related Accession: | Q9P0J0 |
Molecular Weight: | |
NCBI Full Name: | NADH dehydrogenase |
NCBI Synonym Full Names: | NADH:ubiquinone oxidoreductase subunit A13 |
NCBI Official Symbol: | NDUFA13 |
NCBI Official Synonym Symbols: | B16.6; CDA016; CGI-39; GRIM19; GRIM-19; MC1DN28 |
NCBI Protein Information: | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 |
UniProt Protein Name: | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 |
UniProt Synonym Protein Names: | Cell death regulatory protein GRIM-19; Complex I-B16.6; CI-B16.6; Gene associated with retinoic and interferon-induced mortality 19 protein; GRIM-19; Gene associated with retinoic and IFN-induced mortality 19 protein; NADH-ubiquinone oxidoreductase B16.6 subunit |
UniProt Gene Name: | NDUFA13 |
UniProt Entry Name: | NDUAD_HUMAN |
Antibodies |
Anti-NDUFA13 Antibody (CAB5412) |
Anti-NDUFA13 Antibody (CAB18071)[KO Validated] |
Anti-GRIM19 Antibody (CAB3782) |
NDUFA13 Antibody (PACO10775) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |