NCOA6 Antibody, Biotin conjugated (PACO46057)
- SKU:
- PACO46057
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | NCOA6 Antibody, Biotin conjugated (PACO46057) |
抗体コード: | PACO46057 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Nuclear receptor coactivator 6 protein (285-504AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, Rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. |
シノニム: | Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein), NCOA6, AIB3 KIAA0181 RAP250 TRBP |
NCBI Summary: | The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011] |
UniProt Code: | Q14686 |
NCBI GenInfo Identifier: | 32307128 |
NCBI Gene ID: | 23054 |
NCBI Accession: | NP_054790 |
UniProt Related Accession: | Q14686 |
Molecular Weight: | |
NCBI Full Name: | nuclear receptor coactivator 6 isoform 1 |
NCBI Synonym Full Names: | nuclear receptor coactivator 6 |
NCBI Official Symbol: | NCOA6 |
NCBI Official Synonym Symbols: | NRC; AIB3; ASC2; PRIP; TRBP; RAP250 |
NCBI Protein Information: | nuclear receptor coactivator 6 |
UniProt Protein Name: | Nuclear receptor coactivator 6 |
UniProt Synonym Protein Names: | Activating signal cointegrator 2; ASC-2; Amplified in breast cancer protein 3; Cancer-amplified transcriptional coactivator ASC-2; Nuclear receptor coactivator RAP250; NRC RAP250; Nuclear receptor-activating protein, 250 kDa; Peroxisome proliferator-activated receptor-interacting protein; PPAR-interacting protein; PRIP; Thyroid hormone receptor-binding protein |
Protein Family: | Nuclear receptor coactivator |
UniProt Gene Name: | NCOA6 |
UniProt Entry Name: | NCOA6_HUMAN |