NANOS3 Antibody (PACO49790)
- SKU:
- PACO49790
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | NANOS3 Antibody (PACO49790) |
抗体コード: | PACO49790 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Nanos homolog 3 protein (21-192AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO49790 at dilution of 1:100. | |
Immunofluorescent analysis of Hela cells using PACO49790 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis. |
シノニム: | Nanos homolog 3 (NOS-3), NANOS3, NOS3 |
UniProt Protein Function: | NANOS3: Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax- dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis. Belongs to the nanos family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:RNA-binding; Cell development/differentiation Chromosomal Location of Human Ortholog: 19p13.13 Cellular Component: perinuclear region of cytoplasm; stress granule; cytoplasm; nucleus Molecular Function:protein binding; zinc ion binding; RNA binding Biological Process: oogenesis; regulation of translation; regulation of cell cycle; multicellular organismal development; negative regulation of translation; spermatogenesis; germ cell development |
UniProt Code: | P60323 |
NCBI GenInfo Identifier: | 41688563 |
NCBI Gene ID: | 342977 |
NCBI Accession: | P60323.1 |
UniProt Related Accession: | P60323 |
Molecular Weight: | Observed Molecular Weight: (Observed)18kD.Predicted Molecular Weight: (Calculated)19kDa. |
NCBI Full Name: | Nanos homolog 3 |
NCBI Synonym Full Names: | nanos C2HC-type zinc finger 3 |
NCBI Official Symbol: | NANOS3 |
NCBI Official Synonym Symbols: | NOS3; NANOS1L; ZC2HC12C |
NCBI Protein Information: | nanos homolog 3 |
UniProt Protein Name: | Nanos homolog 3 |
Protein Family: | Nanos |
UniProt Gene Name: | NANOS3 |
UniProt Entry Name: | NANO3_HUMAN |