MYO10 Antibody, FITC conjugated (PACO28464)
- SKU:
- PACO28464
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | MYO10 Antibody, FITC conjugated (PACO28464) |
抗体コード: | PACO28464 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Unconventional myosin-X protein (1-97AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. |
シノニム: | Unconventional myosin-X (Unconventional myosin-10), MYO10, KIAA0799 |
UniProt Protein Function: | MYO10: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. Plays a role in formation of the podosome belt in osteoclasts. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Motor Chromosomal Location of Human Ortholog: 5p15.1 Cellular Component: cytosol; filopodium tip; nucleolus; plasma membrane Molecular Function:actin filament binding; actin-dependent ATPase activity; motor activity; phosphatidylinositol-3,4,5-triphosphate binding; plus-end directed microfilament motor activity; protein binding; spectrin binding Biological Process: cytoskeleton-dependent intracellular transport; regulation of cell shape; regulation of filopodium formation |
NCBI Summary: | This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q9HD67 |
NCBI GenInfo Identifier: | 205371854 |
NCBI Gene ID: | 4651 |
NCBI Accession: | Q9HD67.3 |
UniProt Secondary Accession: | Q9HD67,O94893, Q8IVX5, Q9NYM7, Q9P110, Q9P111, Q9UHF6 A7E2D1, |
UniProt Related Accession: | Q9HD67 |
Molecular Weight: | 237kDa |
NCBI Full Name: | Unconventional myosin-X |
NCBI Synonym Full Names: | myosin X |
NCBI Official Symbol: | MYO10 |
NCBI Protein Information: | unconventional myosin-X |
UniProt Protein Name: | Unconventional myosin-X |
UniProt Synonym Protein Names: | Unconventional myosin-10 |
Protein Family: | Unconventional myosin |
UniProt Gene Name: | MYO10 |