MYLIP Antibody (PACO06664)
- SKU:
- PACO06664
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MYLIP Antibody (PACO06664) |
抗体コード: | PACO06664 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthesized peptide derived from the Internal region of human MYLIP. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot analysis of Hela Jurkat cells using MYLIP Polyclonal Antibody. |
![]() | Western Blot analysis of Jurkat cells using MYLIP Polyclonal Antibody. |
シノニム: | MYLIP; BZF1; IDOL; BM-023; PP5242; E3 ubiquitin-protein ligase MYLIP; Inducible degrader of the LDL-receptor; Idol; Myosin regulatory light chain interacting protein; MIR |
UniProt Protein Function: | MYLIP: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol- dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ligase; Ubiquitin ligase; EC 6.3.2.19; EC 6.3.2.-; Motility/polarity/chemotaxis; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 6p22.3 Cellular Component: extrinsic to membrane; cytoskeleton; cytoplasm; plasma membrane; intracellular Molecular Function:protein binding; zinc ion binding; cytoskeletal protein binding; ubiquitin-protein ligase activity; ligase activity Biological Process: nervous system development; cholesterol homeostasis; protein destabilization; protein ubiquitination during ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; protein ubiquitination; regulation of low-density lipoprotein receptor catabolic process; cell motility |
NCBI Summary: | The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8WY64 |
NCBI GenInfo Identifier: | 38788243 |
NCBI Gene ID: | 29116 |
NCBI Accession: | NP_037394.2 |
UniProt Secondary Accession: | Q8WY64,Q5TIA4, Q9BU73, Q9NRL9, Q9UHE7, |
UniProt Related Accession: | Q8WY64 |
Molecular Weight: | 49,910 Da |
NCBI Full Name: | E3 ubiquitin-protein ligase MYLIP |
NCBI Synonym Full Names: | myosin regulatory light chain interacting protein |
NCBI Official Symbol: | MYLIP |
NCBI Official Synonym Symbols: | MIR; IDOL |
NCBI Protein Information: | E3 ubiquitin-protein ligase MYLIP; band 4.1 superfamily member BZF1; inducible degrader of the LDL-receptor; cellular modulator of immune recognition (c-MIR); myosin regulatory light chain-interacting protein; E3 ubiquitin ligase-inducible degrader of the |
UniProt Protein Name: | E3 ubiquitin-protein ligase MYLIP |
UniProt Synonym Protein Names: | Inducible degrader of the LDL-receptor; Idol; Myosin regulatory light chain interacting protein |
UniProt Gene Name: | MYLIP |
UniProt Entry Name: | MYLIP_HUMAN |