MYCN Antibody (PACO20109)
- SKU:
- PACO20109
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MYCN Antibody (PACO20109) |
抗体コード: | PACO20109 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthetic peptide of human MYCN |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20109(MYCN Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20109(MYCN Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. |
シノニム: | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog |
UniProt Protein Function: | N-Myc: a proto-oncogenic transcription factor. Plays a role in cell proliferation, apoptosis and in the development of human tumors. |
UniProt Protein Details: | Protein type:Oncoprotein; DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 2p24.3 Cellular Component: nucleus; chromatin Molecular Function:protein dimerization activity; protein binding; DNA binding; transcription factor activity Biological Process: regulation of transcription from RNA polymerase II promoter; branching morphogenesis of a tube; positive regulation of mesenchymal cell proliferation; negative regulation of astrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; lung development; cartilage condensation; embryonic skeletal morphogenesis Disease: Feingold Syndrome 1; Tracheoesophageal Fistula With Or Without Esophageal Atresia |
NCBI Summary: | This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014] |
UniProt Code: | P04198 |
NCBI GenInfo Identifier: | 127604 |
NCBI Gene ID: | 4613 |
NCBI Accession: | P04198.2 |
UniProt Secondary Accession: | P04198,Q53XS5, Q6LDT9, |
UniProt Related Accession: | P04198 |
Molecular Weight: | 65kDa |
NCBI Full Name: | N-myc proto-oncogene protein |
NCBI Synonym Full Names: | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog |
NCBI Official Symbol: | MYCN |
NCBI Official Synonym Symbols: | NMYC; ODED; MODED; N-myc; bHLHe37 |
NCBI Protein Information: | N-myc proto-oncogene protein; pp65/67; oncogene NMYC; neuroblastoma MYC oncogene; class E basic helix-loop-helix protein 37; neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene |
UniProt Protein Name: | N-myc proto-oncogene protein |
UniProt Synonym Protein Names: | Class E basic helix-loop-helix protein 37; bHLHe37 |
Protein Family: | N-myc protein |
UniProt Gene Name: | MYCN |
UniProt Entry Name: | MYCN_HUMAN |