MYBPC3 Antibody, Biotin conjugated (PACO48569)
- SKU:
- PACO48569
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | MYBPC3 Antibody, Biotin conjugated (PACO48569) |
抗体コード: | PACO48569 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Myosin-binding protein C, cardiac-type protein (1-328AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
シノニム: | Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform), MYBPC3 |
UniProt Protein Function: | MYBPC3: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Belongs to the immunoglobulin superfamily. MyBP family. |
UniProt Protein Details: | Protein type:Myosin-binding Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: A band; cytosol; sarcomere; striated muscle thick filament Molecular Function:ATPase activator activity; identical protein binding; myosin binding; myosin heavy chain binding; protein binding; structural constituent of muscle Biological Process: cardiac muscle contraction; heart morphogenesis; muscle filament sliding; positive regulation of ATPase activity; regulation of muscle filament sliding; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis Disease: Cardiomyopathy, Familial Hypertrophic, 4; Left Ventricular Noncompaction 10 |
NCBI Summary: | MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q14896 |
NCBI GenInfo Identifier: | 425906074 |
NCBI Gene ID: | 4607 |
NCBI Accession: | Q14896.4 |
UniProt Secondary Accession: | Q14896,Q16410, Q6R2F7, Q9UE27, Q9UM53, A5PL00, |
UniProt Related Accession: | Q14896 |
Molecular Weight: | 140,703 Da |
NCBI Full Name: | Myosin-binding protein C, cardiac-type |
NCBI Synonym Full Names: | myosin binding protein C, cardiac |
NCBI Official Symbol: | MYBPC3 |
NCBI Official Synonym Symbols: | FHC; CMH4; CMD1MM; LVNC10; MYBP-C |
NCBI Protein Information: | myosin-binding protein C, cardiac-type |
UniProt Protein Name: | Myosin-binding protein C, cardiac-type |
UniProt Synonym Protein Names: | C-protein, cardiac muscle isoform |
Protein Family: | Myosin-binding protein |
UniProt Gene Name: | MYBPC3 |
UniProt Entry Name: | MYPC3_HUMAN |