UniProt Protein Function: | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
NCBI Summary: | This gene encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skeletal muscle isoform of myosin-binding protein C and plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments. Mutations in this gene are associated with distal arthrogryposis type I. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q00872 |
NCBI GenInfo Identifier: | 6166597 |
NCBI Gene ID: | 4604 |
NCBI Accession: | Q00872.2 |
UniProt Secondary Accession: | Q00872,Q15497, Q17RR7, Q569K7, B4DKR5, B7Z8G8, B7ZL02 B7ZL09, B7ZL10, E7ESM5, E7EWS6, G3XAE8, |
UniProt Related Accession: | Q00872 |
Molecular Weight: | 129,074 Da |
NCBI Full Name: | Myosin-binding protein C, slow-type |
NCBI Synonym Full Names: | myosin binding protein C, slow type |
NCBI Official Symbol: | MYBPC1 |
NCBI Official Synonym Symbols: | LCCS4; MYBPCC; MYBPCS |
NCBI Protein Information: | myosin-binding protein C, slow-type |
UniProt Protein Name: | Myosin-binding protein C, slow-type |
UniProt Synonym Protein Names: | C-protein, skeletal muscle slow isoform |
Protein Family: | Myosin-binding protein |
UniProt Gene Name: | MYBPC1 |
UniProt Entry Name: | MYPC1_HUMAN |