MUTYH Antibody (PACO10662)
- SKU:
- PACO10662
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MUTYH Antibody (PACO10662) |
抗体コード: | PACO10662 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human MUTYH |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | mutY homolog (E. coli);MUTYH;MGC4416;MYH ; |
UniProt Protein Function: | MUTYH: Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2- OH-A DNA glycosylase activities. Belongs to the Nth/MutY family. 6 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Mitochondrial; DNA repair, damage; Tumor suppressor; Hydrolase; EC 3.2.2.- Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: nucleoplasm; nucleus Molecular Function:DNA N-glycosylase activity; MutLalpha complex binding; MutLbeta complex binding; MutSalpha complex binding; MutSbeta complex binding; protein binding Biological Process: depurination; DNA repair; mismatch repair Disease: Familial Adenomatous Polyposis, 2; Gastric Cancer; Pilomatrixoma |
NCBI Summary: | This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UIF7 |
NCBI GenInfo Identifier: | 48428272 |
NCBI Gene ID: | 4595 |
NCBI Accession: | Q9UIF7.1 |
UniProt Secondary Accession: | Q9UIF7,Q15830, Q9UBP2, Q9UBS7, Q9UIF4, Q9UIF5, Q9UIF6 D3DPZ4, |
UniProt Related Accession: | Q9UIF7 |
Molecular Weight: | 57,446 Da |
NCBI Full Name: | Adenine DNA glycosylase |
NCBI Synonym Full Names: | mutY DNA glycosylase |
NCBI Official Symbol: | MUTYH |
NCBI Official Synonym Symbols: | MYH |
NCBI Protein Information: | adenine DNA glycosylase |
UniProt Protein Name: | Adenine DNA glycosylase |
UniProt Synonym Protein Names: | MutY homolog; hMYH |
UniProt Gene Name: | MUTYH |
UniProt Entry Name: | MUTYH_HUMAN |