MUSK Antibody (PACO15671)
- SKU:
- PACO15671
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | MUSK Antibody (PACO15671) |
抗体コード: | PACO15671 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human MUSK |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15671(MUSK Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15671(MUSK Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described. |
シノニム: | muscle, skeletal, receptor tyrosine kinase |
UniProt Protein Function: | MUSK: a receptor tyrosine kinase that is essential for the establishment and maintenance of the neuromuscular junction (NMJ). Its activation by agrin, a neuronally derived heparan-sulfate proteoglycan, and the agrin receptor (LRP4), leads to clustering of acetylcholine receptors on the postsynaptic side of the NMJ. Its activation by agrin requires Dok7, which interacts with the cytoplasmic portion of MuSK and activates its tyrosine kinase activity. |
UniProt Protein Details: | Protein type:Protein kinase, tyrosine (receptor); Membrane protein, integral; Protein kinase, TK; Kinase, protein; EC 2.7.10.1; TK group; Musk family Chromosomal Location of Human Ortholog: 9q31.3-q32 Cellular Component: postsynaptic membrane; integral to plasma membrane; neuromuscular junction; cell junction; receptor complex Molecular Function:protein binding; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: extracellular matrix organization and biogenesis; peptidyl-tyrosine phosphorylation; regulation of transcription, DNA-dependent; positive regulation of neuron apoptosis; protein amino acid autophosphorylation; multicellular organismal development; regulation of synaptic growth at neuromuscular junction; positive regulation of protein amino acid phosphorylation; cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; memory; neuromuscular junction development Disease: Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency; Fetal Akinesia Deformation Sequence |
NCBI Summary: | This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009] |
UniProt Code: | O15146 |
NCBI GenInfo Identifier: | 50400806 |
NCBI Gene ID: | 4593 |
NCBI Accession: | O15146.1 |
UniProt Secondary Accession: | O15146,Q32MJ8, Q32MJ9, Q5VZW7, Q5VZW8, |
UniProt Related Accession: | O15146 |
Molecular Weight: | 86,425 Da |
NCBI Full Name: | Muscle, skeletal receptor tyrosine-protein kinase |
NCBI Synonym Full Names: | muscle, skeletal, receptor tyrosine kinase |
NCBI Official Symbol: | MUSK |
NCBI Protein Information: | muscle, skeletal receptor tyrosine-protein kinase; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor |
UniProt Protein Name: | Muscle, skeletal receptor tyrosine-protein kinase |
UniProt Synonym Protein Names: | Muscle-specific tyrosine-protein kinase receptor; MuSK; Muscle-specific kinase receptor |
Protein Family: | Muskelin |
UniProt Gene Name: | MUSK |
UniProt Entry Name: | MUSK_HUMAN |
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