MTMR2 Antibody, HRP conjugated (PACO55875)
- SKU:
- PACO55875
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Description
抗体名: | MTMR2 Antibody, HRP conjugated (PACO55875) |
抗体コード: | PACO55875 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Myotubularin-related protein 2 protein (1-173AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. |
シノニム: | Myotubularin-related protein 2 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64), MTMR2, KIAA1073 |
UniProt Protein Function: | MTMR2: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. Homooligomer and heterooligomer. Interacts with SBF1 and SBF2. interaction with SBF1 increases phosphatase activity. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. |
UniProt Protein Details: | Protein type:EC 3.1.3.95; Protein phosphatase, tyrosine (non-receptor); Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.3.64; Phosphatase, lipid; Motility/polarity/chemotaxis; Carbohydrate Metabolism - fructose and mannose; Cofactor and Vitamin Metabolism - thiamine Chromosomal Location of Human Ortholog: 11q22 Cellular Component: synaptic vesicle; early endosome membrane; axon; vacuolar membrane; dendrite; cytoplasm; dendritic spine; nucleus; cytosol Molecular Function:protein binding; phosphatidylinositol-3-phosphatase activity; protein homodimerization activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity Biological Process: myelin formation; negative regulation of myelination; inositol phosphate dephosphorylation; negative regulation of endocytosis; phospholipid metabolic process; phosphatidylinositol biosynthetic process; neuron development; phosphoinositide dephosphorylation; protein amino acid dephosphorylation; protein tetramerization; negative regulation of receptor internalization Disease: Charcot-marie-tooth Disease, Type 4b1 |
NCBI Summary: | This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011] |
UniProt Code: | Q13614 |
NCBI GenInfo Identifier: | 343790884 |
NCBI Gene ID: | 8898 |
NCBI Accession: | NP_001230500.1 |
UniProt Secondary Accession: | Q13614,Q9UPS9, A6NN98, |
UniProt Related Accession: | Q13614 |
Molecular Weight: | 73,381 Da |
NCBI Full Name: | myotubularin-related protein 2 isoform 2 |
NCBI Synonym Full Names: | myotubularin related protein 2 |
NCBI Official Symbol: | MTMR2 |
NCBI Official Synonym Symbols: | CMT4B; CMT4B1 |
NCBI Protein Information: | myotubularin-related protein 2 |
UniProt Protein Name: | Myotubularin-related protein 2 |
Protein Family: | Myotubularin-related protein |
UniProt Gene Name: | MTMR2 |
UniProt Entry Name: | MTMR2_HUMAN |