MTHFS Antibody (PACO28418)
- SKU:
- PACO28418
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MTHFS Antibody (PACO28418) |
抗体コード: | PACO28418 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human 5-formyltetrahydrofolate cyclo-ligase protein (2-203AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot All lanes: MTHFS antibody at 2µg/ml + Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 24, 21 kDa Observed band size: 24 kDa . |
![]() | Immunofluorescent analysis of MCF-7 cells using PACO28418 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | Immunohistochemistry of paraffin-embedded human lung tissue using PACO28418 at dilution of 1:100. |
バックグラウンド: | Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acid, . Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate. |
シノニム: | 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) (5,10-methenyl-tetrahydrofolate synthetase) (MTHFS) (Methenyl-THF synthetase), MTHFS |
UniProt Protein Function: | Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate. |
NCBI Summary: | The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] |
UniProt Code: | P49914 |
NCBI GenInfo Identifier: | 1706921 |
NCBI Gene ID: | 10588 |
NCBI Accession: | P49914.2 |
UniProt Related Accession: | P49914 |
Molecular Weight: | 20kDa; 23kDa |
NCBI Full Name: | 5-formyltetrahydrofolate cyclo-ligase |
NCBI Synonym Full Names: | methenyltetrahydrofolate synthetase |
NCBI Official Symbol: | MTHFS |
NCBI Official Synonym Symbols: | NEDMEHM; HsT19268 |
NCBI Protein Information: | 5-formyltetrahydrofolate cyclo-ligase |
UniProt Protein Name: | 5-formyltetrahydrofolate cyclo-ligase |
UniProt Synonym Protein Names: | 5,10-methenyl-tetrahydrofolate synthetase; MTHFS; Methenyl-THF synthetase |
UniProt Gene Name: | MTHFS |
UniProt Entry Name: | MTHFS_HUMAN |