MTHFD2 Antibody (PACO10640)
- SKU:
- PACO10640
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MTHFD2 Antibody (PACO10640) |
抗体コード: | PACO10640 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human MTHFD2 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase;MTHFD2;NMDMC ; |
UniProt Protein Function: | MTHFD2: a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009] |
UniProt Protein Details: | Protein type:Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 3.5.4.9; Hydrolase; Oxidoreductase; EC 1.5.1.15; Mitochondrial; Cofactor and Vitamin Metabolism - one carbon pool by folate Chromosomal Location of Human Ortholog: 2p13.1 Cellular Component: cytosol; extracellular space; mitochondrial matrix; mitochondrion Molecular Function:formate-tetrahydrofolate ligase activity; magnesium ion binding; methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; methylenetetrahydrofolate dehydrogenase (NADP+) activity; phosphate binding Biological Process: folic acid metabolic process; one-carbon compound metabolic process; tetrahydrofolate metabolic process |
NCBI Summary: | This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009] |
UniProt Code: | P13995 |
NCBI GenInfo Identifier: | 115311607 |
NCBI Gene ID: | 10797 |
NCBI Accession: | P13995.2 |
UniProt Secondary Accession: | P13995,Q53G90, Q53GV5, Q53S36, Q7Z650, |
UniProt Related Accession: | P13995 |
Molecular Weight: | 26,849 Da |
NCBI Full Name: | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial |
NCBI Synonym Full Names: | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
NCBI Official Symbol: | MTHFD2 |
NCBI Official Synonym Symbols: | NMDMC |
NCBI Protein Information: | bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial |
UniProt Protein Name: | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial |
Protein Family: | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase |
UniProt Gene Name: | MTHFD2 |
UniProt Entry Name: | MTDC_HUMAN |