MTAP Antibody (PACO48606)
- SKU:
- PACO48606
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MTAP Antibody (PACO48606) |
抗体コード: | PACO48606 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:2000-1:10000, IF:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human S-methyl-5'-thioadenosine phosphorylase protein (1-283AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: NIH/3T3 whole cell lysate, Mouse liver tissue, Mouse kidney tissue. All lanes: MTAP antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 32, 39, 37, 31, 34, 33, 27 kDa. Observed band size: 32, 39 kDa.. |
![]() | Immunofluorescent analysis of U251 cells using PACO48606 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. |
シノニム: | S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase), MTAP, MSAP |
UniProt Protein Function: | MTAP: Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates. Homotrimer. Ubiquitously expressed. Inhibited by 5'-methylthiotubercin and 5'- chloroformycin. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - cysteine and methionine; EC 2.4.2.28; Phosphorylase; Transferase Chromosomal Location of Human Ortholog: 9p21.3 Cellular Component: cytoplasm; cytosol Molecular Function:phosphorylase activity; protein binding; S-methyl-5-thioadenosine phosphorylase activity Biological Process: methionine salvage; nicotinamide riboside catabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; purine salvage |
NCBI Summary: | This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q13126 |
NCBI GenInfo Identifier: | 143811423 |
NCBI Gene ID: | 4507 |
NCBI Accession: | Q13126.2 |
UniProt Secondary Accession: | Q13126,Q5T3P3, Q9H010, I2G7M5, I2G7M6, I2G7M7, I2G7M8 I2G7M9, I2G7N0, |
UniProt Related Accession: | Q13126 |
Molecular Weight: | 26,278 Da |
NCBI Full Name: | S-methyl-5'-thioadenosine phosphorylase |
NCBI Synonym Full Names: | methylthioadenosine phosphorylase |
NCBI Official Symbol: | MTAP |
NCBI Official Synonym Symbols: | BDMF; MSAP; DMSFH; LGMBF; DMSMFH; c86fus; HEL-249 |
NCBI Protein Information: | S-methyl-5'-thioadenosine phosphorylase |
UniProt Protein Name: | S-methyl-5'-thioadenosine phosphorylase |
UniProt Synonym Protein Names: | 5'-methylthioadenosine phosphorylase |
UniProt Gene Name: | MTAP |