MSRB1 Antibody, Biotin conjugated (PACO53189)
- SKU:
- PACO53189
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | MSRB1 Antibody, Biotin conjugated (PACO53189) |
抗体コード: | PACO53189 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Methionine-R-sulfoxide reductase B1 protein (1-116AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages (By similarity). |
シノニム: | Methionine-R-sulfoxide reductase B1 (MsrB1) (EC 1.8.4.12) (EC 1.8.4.14) (Selenoprotein X) (SelX), MSRB1, SEPX1 |
UniProt Protein Function: | SEPX1: a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the methionine sulfoxide reductase (Msr) protein family which includes repair enzymes that reduce oxidized methionine residues in proteins. The protein encoded by this gene is expressed in a variety of adult and fetal tissues and localizes to the cell nucleus and cytosol. [provided by RefSeq, Mar 2012] |
UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.8.4.- Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: cytoplasm; nucleus; actin cytoskeleton Molecular Function:zinc ion binding; peptide-methionine (R)-S-oxide reductase activity; actin binding Biological Process: protein repair; actin filament polymerization; innate immune response; response to oxidative stress |
NCBI Summary: | The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A pseudogene of this locus has been identified on chromosome 19. [provided by RefSeq, Aug 2017] |
UniProt Code: | Q9NZV6 |
NCBI GenInfo Identifier: | 182676387 |
NCBI Gene ID: | 51734 |
NCBI Accession: | Q9NZV6.3 |
UniProt Related Accession: | Q9NZV6 |
Molecular Weight: | 13kDa |
NCBI Full Name: | Methionine-R-sulfoxide reductase B1 |
NCBI Synonym Full Names: | methionine sulfoxide reductase B1 |
NCBI Official Symbol: | MSRB1 |
NCBI Official Synonym Symbols: | SELR; SELX; SepR; SEPX1; HSPC270 |
NCBI Protein Information: | methionine-R-sulfoxide reductase B1 |
UniProt Protein Name: | Methionine-R-sulfoxide reductase B1 |
UniProt Synonym Protein Names: | Selenoprotein X; SelX |
Protein Family: | Methionine-R-sulfoxide reductase |
UniProt Gene Name: | MSRB1 |
UniProt Entry Name: | MSRB1_HUMAN |