UniProt Protein Function: | MRC1: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Chromosomal Location of Human Ortholog: 10p12.33 Cellular Component: endosome membrane; integral to plasma membrane; plasma membrane Molecular Function:protein binding; receptor activity; transmembrane receptor activity Biological Process: receptor-mediated endocytosis |
NCBI Summary: | The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015] |
UniProt Code: | P22897 |
NCBI GenInfo Identifier: | 126730 |
NCBI Gene ID: | 4360 |
NCBI Accession: | P22897.1 |
UniProt Secondary Accession: | P22897,Q5VSJ2, Q5VSK2, A5PKW3, |
UniProt Related Accession: | P22897 |
Molecular Weight: | 166kDa |
NCBI Full Name: | Macrophage mannose receptor 1 |
NCBI Synonym Full Names: | mannose receptor C-type 1 |
NCBI Official Symbol: | MRC1 |
NCBI Official Synonym Symbols: | MMR; hMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1 |
NCBI Protein Information: | macrophage mannose receptor 1 |
UniProt Protein Name: | Macrophage mannose receptor 1 |
UniProt Synonym Protein Names: | C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; Human mannose receptor; hMR; Macrophage mannose receptor 1-like protein 1; CD_antigen: CD206 |
Protein Family: | Macrophage mannose receptor |
UniProt Gene Name: | MRC1 |