MRAP Antibody (PACO10565)
- SKU:
- PACO10565
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MRAP Antibody (PACO10565) |
抗体コード: | PACO10565 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human MRAP |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | melanocortin 2 receptor accessory protein;MRAP;B27;C21orf61;FALP;FGD2;GCCD2 ; |
UniProt Protein Function: | MRAP: Required for MC2R expression in certain cell types, suggesting that it is involved in the processing, trafficking or function of MC2R. May be involved in the intracellular trafficking pathways in adipocyte cells. Defects in MRAP are the cause of glucocorticoid deficiency type 2 (GCCD2); also known as familial glucocorticoid deficiency type 2 (FGD2). GCCD2 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 21q22.1Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; plasma membrane; integral to membraneMolecular Function: type 5 melanocortin receptor binding; type 3 melanocortin receptor binding; protein binding; type 4 melanocortin receptor binding; adrenocorticotropin hormone receptor bindingBiological Process: positive regulation of cAMP biosynthetic process; brown fat cell differentiationDisease: Glucocorticoid Deficiency 2 |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009] |
UniProt Code: | Q8TCY5 |
NCBI GenInfo Identifier: | 45827704 |
NCBI Gene ID: | 56246 |
NCBI Accession: | NP_996781.1 |
UniProt Secondary Accession: | Q8TCY5,Q5EBR3, Q8TDB7, Q8WXC1, Q8WXC2 |
UniProt Related Accession: | Q8TCY5 |
Molecular Weight: | 19,136 Da |
NCBI Full Name: | melanocortin-2 receptor accessory protein isoform beta |
NCBI Synonym Full Names: | melanocortin 2 receptor accessory protein |
NCBI Official Symbol: | MRAP |
NCBI Official Synonym Symbols: | B27; FALP; FGD2; GCCD2; C21orf61 |
NCBI Protein Information: | melanocortin-2 receptor accessory protein; fat tissue-specific low MW protein; fat cell-specific low molecular weight protein |
UniProt Protein Name: | Melanocortin-2 receptor accessory protein |
UniProt Synonym Protein Names: | B27; Fat cell-specific low molecular weight protein; Fat tissue-specific low MW protein |
Protein Family: | Melanocortin-2 receptor accessory protein |
UniProt Gene Name: | MRAP |
UniProt Entry Name: | MRAP_HUMAN |