MPZL1 Antibody, Biotin conjugated (PACO47557)
- SKU:
- PACO47557
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | MPZL1 Antibody, Biotin conjugated (PACO47557) |
抗体コード: | PACO47557 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Myelin protein zero-like protein 1 protein (195-258AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. |
シノニム: | Myelin protein zero-like protein 1 (Protein zero-related), MPZL1, PZR |
UniProt Protein Function: | PZR: an immunoglobulin superfamily cell surface protein. Contains two tyrosine-based inhibition motifs (ITIMs) responsible for binding of SHP-2. When phosphorylated, it can specifically bind SHP-2, blocking its translocation, and interupting its function. Treatment of several cell lines with ConA caused tyrosine phosphorylation of PZR. Two alternatively spliced isoforms have been reported. One isoform, PZR1b, lacks the ITIMs and has a dominant negative effect upon full-length PZR and its recruitment of SHP-2. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q24.2 Cellular Component: focal adhesion; cell surface; integral to plasma membrane Molecular Function:protein binding; structural molecule activity Biological Process: cell-cell signaling; transmembrane receptor protein tyrosine kinase signaling pathway |
UniProt Code: | O95297 |
NCBI GenInfo Identifier: | 226054871 |
NCBI Gene ID: | 9019 |
NCBI Accession: | NP_001139663.1 |
UniProt Related Accession: | O95297 |
Molecular Weight: | Observed: 29 kDaPredicted: 30 kDa |
NCBI Full Name: | myelin protein zero-like protein 1 isoform c |
NCBI Synonym Full Names: | myelin protein zero like 1 |
NCBI Official Symbol: | MPZL1 |
NCBI Official Synonym Symbols: | PZR; PZRa; PZRb; PZR1b; MPZL1b |
NCBI Protein Information: | myelin protein zero-like protein 1 |
UniProt Protein Name: | Myelin protein zero-like protein 1 |
UniProt Synonym Protein Names: | Protein zero-related |
UniProt Gene Name: | MPZL1 |
UniProt Entry Name: | MPZL1_HUMAN |