MPP5 Antibody (PACO10556)
- SKU:
- PACO10556
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MPP5 Antibody (PACO10556) |
抗体コード: | PACO10556 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human MPP5 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5);MPP5;FLJ12615;PALS1 ; |
UniProt Protein Function: | MPP5: May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton. Belongs to the MAGUK family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 14q23.3 Cellular Component: nucleoplasm; protein complex; tight junction; lateral loop; cytoplasm; plasma membrane; endomembrane system Molecular Function:protein domain specific binding; protein binding Biological Process: intercellular junction assembly and maintenance; myelin formation; myelin maintenance in the peripheral nervous system; morphogenesis of an epithelial sheet |
NCBI Summary: | This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] |
UniProt Code: | Q8N3R9 |
NCBI GenInfo Identifier: | 116242632 |
NCBI Gene ID: | 64398 |
NCBI Accession: | Q8N3R9.3 |
UniProt Related Accession: | Q8N3R9 |
Molecular Weight: | 73kDa; 77kDa |
NCBI Full Name: | MAGUK p55 subfamily member 5 |
NCBI Synonym Full Names: | membrane palmitoylated protein 5 |
NCBI Official Symbol: | MPP5 |
NCBI Official Synonym Symbols: | PALS1 |
NCBI Protein Information: | MAGUK p55 subfamily member 5 |
UniProt Protein Name: | MAGUK p55 subfamily member 5 |
Protein Family: | MAGUK p55 subfamily |
UniProt Gene Name: | MPP5 |
UniProt Entry Name: | MPP5_HUMAN |