MORF4L1 Antibody (PACO20427)
- SKU:
- PACO20427
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MORF4L1 Antibody (PACO20427) |
抗体コード: | PACO20427 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthetic peptide of human MORF4L1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20427(MORF4L1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20427(MORF4L1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | MORF4L1 (also known as MRG15) and MORF4-related gene X (MRGX). The human MORF4 gene maps to chromosome 4q33-q34.1. MORF4 induces a senescent-like phenotype in complementation group B immortal cell lines. The genes encoding MRG15 and MRGX map to chromosomes 15q24 and Xq22, respectively. MORF4, MORF4L1 and MRGX each contain a C-terminal leucine zipper. An association between MORF4L1, Rb (retinoblastoma tumor suppressor) and PAM14 (protein associated with MORF4L1) suggests a role for MORF4L1 in transcription regulation. |
シノニム: | mortality factor 4 like 1 |
UniProt Protein Function: | MORF4L1: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 15q24 Cellular Component: nucleoplasm; NuA4 histone acetyltransferase complex; Sin3 complex Molecular Function:protein binding; protein N-terminus binding; chromatin binding Biological Process: cell proliferation; establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent; regulation of growth; histone deacetylation; double-strand break repair via homologous recombination |
UniProt Code: | Q9UBU8 |
NCBI GenInfo Identifier: | 59803121 |
NCBI Gene ID: | 10933 |
NCBI Accession: | Q9UBU8.2 |
UniProt Secondary Accession: | Q9UBU8,O95899, Q5QTS1, Q6NVX8, Q86YT7, Q9HBP6, Q9NSW5 B4DKN6, B7Z6R1, D3DW88, |
UniProt Related Accession: | Q9UBU8 |
Molecular Weight: | 362 |
NCBI Full Name: | Mortality factor 4-like protein 1 |
NCBI Synonym Full Names: | mortality factor 4 like 1 |
NCBI Official Symbol: | MORF4L1 |
NCBI Official Synonym Symbols: | Eaf3; MEAF3; MRG15; FWP006; S863-6; HsT17725; MORFRG15 |
NCBI Protein Information: | mortality factor 4-like protein 1; protein MSL3-1; MORF-related gene 15 protein; Esa1p-associated factor 3 homolog; MORF-related gene on chromosome 15; transcription factor-like protein MRG15 |
UniProt Protein Name: | Mortality factor 4-like protein 1 |
UniProt Synonym Protein Names: | MORF-related gene 15 protein; Protein MSL3-1; Transcription factor-like protein MRG15 |
Protein Family: | Mortality factor 4-like protein |
UniProt Gene Name: | MORF4L1 |
UniProt Entry Name: | MO4L1_HUMAN |