MLLT4 Antibody (PACO49770)
- SKU:
- PACO49770
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MLLT4 Antibody (PACO49770) |
抗体コード: | PACO49770 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Afadin protein (1663-1809AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO49770 at dilution of 1:100. |
![]() | Immunofluorescent analysis of U251 cells using PACO49770 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. |
シノニム: | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor), AFDN, AF6 MLLT4 |
UniProt Protein Function: | Afadin: plays a role in adhesion by participating, along with E-cadherin and catenin, in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Essential for the association of nectin and E-cadherin. Contains 1 forkhead-associated (FHA) domain, a phosphopeptide recognition domain; 1 dilute (DIL) domain, a myosin-like domain which may play a functional role in cellular processes or vectorial vesicle transport; 1 PDZ domain, which frequently binds the carboxyl-terminal sequences of proteins or phosphatidylinositol 4,5-bisphosphate in the plasma membrane; and 2 RA domains, which are associated with RasGTP effector activity. Five alternatively spliced isoforms have been described. Isoform 2 does not interact with F-actin. Protein type: Oncoprotein; Motility/polarity/chemotaxis; Cell adhesionChromosomal Location of Human Ortholog: 6q27Cellular Component: nucleoplasm; cell-cell adherens junction; apical part of cell; cytoplasm; plasma membrane; intercellular junction; cytosol; cell junctionMolecular Function: protein C-terminus binding; protein binding; Ras GTPase binding; cell adhesion molecule bindingBiological Process: intercellular junction assembly and maintenance; cell-cell signaling; cell adhesion; signal transduction |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011] |
UniProt Code: | P55196 |
NCBI GenInfo Identifier: | 288558835 |
NCBI Gene ID: | 4301 |
NCBI Accession: | P55196.3 |
UniProt Secondary Accession: | P55196,O75087, O75088, O75089, Q59FP0, Q5TIG6, Q5TIG7 Q9NSN7, Q9NU92 |
UniProt Related Accession: | P55196 |
Molecular Weight: | 1824 |
NCBI Full Name: | Afadin |
NCBI Synonym Full Names: | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 |
NCBI Official Symbol: | MLLT4 |
NCBI Official Synonym Symbols: | AF6 |
NCBI Protein Information: | afadin; protein AF-6; ALL1-fused gene from chromosome 6 protein |
UniProt Protein Name: | Afadin |
UniProt Synonym Protein Names: | ALL1-fused gene from chromosome 6 protein; Protein AF-6 |
Protein Family: | Afadin |
UniProt Gene Name: | MLLT4 |
UniProt Entry Name: | AFAD_HUMAN |
Antibodies |
MLLT4 Antibody (PACO10512) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |