MIP Antibody, Biotin conjugated (PACO57863)
- SKU:
- PACO57863
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | MIP Antibody, Biotin conjugated (PACO57863) |
抗体コード: | PACO57863 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Lens fiber major intrinsic protein (220-263AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling. |
シノニム: | Lens fiber major intrinsic protein (Aquaporin-0) (MIP26) (MP26), MIP, AQP0 |
UniProt Protein Function: | AQP0: major intrinsic protein of lens fiber. A member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. May be responsible for regulating the osmolarity of the lens. Defects in MIP are a cause of autosomal recessive congenital cataract. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Channel, misc.; Transporter, aquaporin family Chromosomal Location of Human Ortholog: 12q13 Cellular Component: intracellular canaliculus; intracellular membrane-bound organelle; integral to plasma membrane; apical plasma membrane; plasma membrane; gap junction Molecular Function:calmodulin binding; transporter activity; water channel activity; structural constituent of eye lens; glycerol channel activity Biological Process: lens development in camera-type eye; glycerol transport; cellular water homeostasis; visual perception; canalicular bile acid transport; water transport; response to stimulus; transmembrane transport Disease: Cataract 15, Multiple Types |
NCBI Summary: | Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008] |
UniProt Code: | P30301 |
NCBI GenInfo Identifier: | 266537 |
NCBI Gene ID: | 4284 |
NCBI Accession: | P30301.1 |
UniProt Secondary Accession: | P30301,Q17R41, |
UniProt Related Accession: | P30301 |
Molecular Weight: | 263 |
NCBI Full Name: | Lens fiber major intrinsic protein |
NCBI Synonym Full Names: | major intrinsic protein of lens fiber |
NCBI Official Symbol: | MIP |
NCBI Official Synonym Symbols: | AQP0; LIM1; MP26; MIP26; CTRCT15 |
NCBI Protein Information: | lens fiber major intrinsic protein; aquaporin 0 |
UniProt Protein Name: | Lens fiber major intrinsic protein |
UniProt Synonym Protein Names: | Aquaporin-0; MIP26; MP26 |
Protein Family: | Mipartoxin |
UniProt Gene Name: | MIP |
UniProt Entry Name: | MIP_HUMAN |