MICU1 Antibody, Biotin conjugated (PACO58447)
- SKU:
- PACO58447
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | MICU1 Antibody, Biotin conjugated (PACO58447) |
抗体コード: | PACO58447 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Calcium uptake protein 1, mitochondrial protein (55-191AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. |
シノニム: | Calcium uptake protein 1, mitochondrial (Atopy-related autoantigen CALC) (ara CALC) (Calcium-binding atopy-related autoantigen 1) (allergen Hom s 4), MICU1, CALC CBARA1 |
UniProt Protein Function: | MICU1: Key regulator of mitochondrial calcium uptake required for calcium entry into mitochondrion. May act as a calcium sensor via its EF-hand domains, gating the activity of a calcium channel partner. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. Belongs to the MICU1 family. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Mitochondrial; Calcium-binding Chromosomal Location of Human Ortholog: 10q22.1 Cellular Component: intracellular; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion Molecular Function:calcium ion binding; identical protein binding; protein binding; protein heterodimerization activity Biological Process: defense response; elevation of mitochondrial calcium ion concentration; mitochondrial calcium ion homeostasis; mitochondrial calcium ion transport; protein homooligomerization Disease: Myopathy With Extrapyramidal Signs |
NCBI Summary: | This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013] |
UniProt Code: | Q9BPX6 |
NCBI GenInfo Identifier: | 74761192 |
NCBI Gene ID: | 10367 |
NCBI Accession: | Q9BPX6.1 |
UniProt Secondary Accession: | Q9BPX6,O75785, Q9H9N6, Q9UFX0, A8MV96, B3KN20, B4DJH9 B4DPI1, B5MBY3, D3YTJ3, |
UniProt Related Accession: | Q9BPX6 |
Molecular Weight: | 31,931 Da |
NCBI Full Name: | Calcium uptake protein 1, mitochondrial |
NCBI Synonym Full Names: | mitochondrial calcium uptake 1 |
NCBI Official Symbol: | MICU1 |
NCBI Official Synonym Symbols: | CALC; EFHA3; MPXPS; CBARA1 |
NCBI Protein Information: | calcium uptake protein 1, mitochondrial |
UniProt Protein Name: | Calcium uptake protein 1, mitochondrial |
UniProt Synonym Protein Names: | Atopy-related autoantigen CALC; ara CALC; Calcium-binding atopy-related autoantigen 1; Allergen: Hom s 4 |
Protein Family: | Calcium uptake protein |
UniProt Gene Name: | MICU1 |
UniProt Entry Name: | MICU1_HUMAN |