MICAL1 Antibody (PACO10488)
- SKU:
- PACO10488
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IP
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MICAL1 Antibody (PACO10488) |
抗体コード: | PACO10488 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IP |
推奨される希釈: | |
反応性: | Human |
免疫原: | Human MICAL1 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | microtubule associated monoxygenase, calponin and LIM domain containing 1;MICAL1;DKFZp434B1517;FLJ11937;FLJ21739;MICAL;MICAL-1;NICAL ; |
UniProt Protein Function: | MICAL1: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Belongs to the Mical family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold; EC 1.14.13.- Chromosomal Location of Human Ortholog: 6q21 Cellular Component: cytoplasm; intermediate filament Molecular Function:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen; protein binding; zinc ion binding; actin binding; SH3 domain binding; Rab GTPase binding Biological Process: actin filament depolymerization; negative regulation of protein amino acid phosphorylation; cytoskeleton organization and biogenesis; negative regulation of caspase activity; signal transduction; sulfur oxidation |
UniProt Code: | Q8TDZ2 |
NCBI GenInfo Identifier: | 45593495 |
NCBI Gene ID: | |
NCBI Accession: | Q8TDZ2.2 |
Molecular Weight: | ~ 132kDa |
NCBI Full Name: | [F-actin]-monooxygenase MICAL1 |
UniProt Protein Name: | Protein-methionine sulfoxide oxidase MICAL1 |
UniProt Synonym Protein Names: | Molecule interacting with CasL protein 1; MICAL-1; NEDD9-interacting protein with calponin homology and LIM domains |
Protein Family: | Protein-methionine sulfoxide oxidase |
UniProt Gene Name: | MICAL1 |
UniProt Entry Name: | MICA1_HUMAN |