MCU Antibody (PACO54170)
- SKU:
- PACO54170
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MCU Antibody (PACO54170) |
抗体コード: | PACO54170 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Calcium uniporter protein, mitochondrial protein (155-233AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: HL60 whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate. All lanes: MCU antibody at 3.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 40, 37, 36 kDa. Observed band size: 40 kDa. |
![]() | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO54170 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO54170 at dilution of 1:100. |
バックグラウンド: | Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells. participates in mitochondrial permeability transition during ischemia-reperfusion injury (By similarity). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity). Involved in antigen processing and presentation (By similarity). |
シノニム: | Calcium uniporter protein, mitochondrial (HsMCU) (Coiled-coil domain-containing protein 109A), MCU, C10orf42 CCDC109A |
UniProt Protein Function: | MCU: Mitochondrial inner membrane calcium transporter that mediates calcium uptake into mitochondrion. Belongs to the MCU family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Mitochondrial; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 10q22.1 Cellular Component: integral to mitochondrial inner membrane; mitochondrial inner membrane; mitochondrion Molecular Function:calcium channel activity; identical protein binding; protein binding; uniporter activity Biological Process: calcium-mediated signaling; elevation of mitochondrial calcium ion concentration; glucose homeostasis; mitochondrial calcium ion transport; positive regulation of insulin secretion |
NCBI Summary: | This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] |
UniProt Code: | Q8NE86 |
NCBI GenInfo Identifier: | 398303803 |
NCBI Gene ID: | 90550 |
NCBI Accession: | NP_001257608.1 |
UniProt Secondary Accession: | Q8NE86,Q96FL3, B2RDF3, B3KXV7, |
UniProt Related Accession: | Q8NE86 |
Molecular Weight: | 35,159 Da |
NCBI Full Name: | calcium uniporter protein, mitochondrial isoform 2 |
NCBI Synonym Full Names: | mitochondrial calcium uniporter |
NCBI Official Symbol: | MCU |
NCBI Official Synonym Symbols: | C10orf42; CCDC109A |
NCBI Protein Information: | calcium uniporter protein, mitochondrial |
UniProt Protein Name: | Calcium uniporter protein, mitochondrial |
UniProt Synonym Protein Names: | Coiled-coil domain-containing protein 109A |
Protein Family: | Calcium uniporter protein |
UniProt Gene Name: | MCU |
UniProt Entry Name: | MCU_HUMAN |