MCPH1 Antibody (PACO05370)
- SKU:
- PACO05370
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MCPH1 Antibody (PACO05370) |
抗体コード: | PACO05370 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:40000, WB:1:500-1:2000, IHC:1:100-1:300 |
反応性: | Human, Mouse |
免疫原: | Synthesized peptide derived from the N-terminal region of human Microcephalin. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | MCPH1; Microcephalin |
UniProt Protein Function: | MCPH1: a DNA damage responsive protein and transcriptional repressor of human telomere reverse transcriptase. An early responder to DNA damage. Required for double strand break repair via homologous recombination and nonhomologous end joining. Promotes chromatin relaxation by recruiting and maintaining the chromatin remodeling SWI-SNF complex at sites of DNA double strand breakage. Participates in the ATR/Chk1-mediated DNA checkpoint in humans and transcriptionally regulates BRCA1 and Chk1. Plays a role in neurogenesis and regulation of the size of the cerebral cortex. Mutations of MCPH1 can cause microcephaly in humans and appears to play an evolutionarily conserved role in brain development. Alterations have been identified in breast, ovarian and prostate cancer. Appears to coordinate S-M transitions in fly embryos. |
UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 8p23.1 Cellular Component: nucleoplasm; cytoplasm; microtubule organizing center Molecular Function:identical protein binding; protein binding Biological Process: cerebral cortex development; mitotic cell cycle Disease: Microcephaly 1, Primary, Autosomal Recessive |
NCBI Summary: | This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010] |
UniProt Code: | Q8NEM0 |
NCBI GenInfo Identifier: | 296439305 |
NCBI Gene ID: | 79648 |
NCBI Accession: | Q8NEM0.3 |
UniProt Secondary Accession: | Q8NEM0,Q66GU1, Q9H9C7, B4DWW2, E9PGU5, E9PH63, |
UniProt Related Accession: | Q8NEM0 |
Molecular Weight: | 835 |
NCBI Full Name: | Microcephalin |
NCBI Synonym Full Names: | microcephalin 1 |
NCBI Official Symbol: | MCPH1 |
NCBI Official Synonym Symbols: | MCT; BRIT1 |
NCBI Protein Information: | microcephalin; BRCT-repeat inhibitor of TERT expression 1 |
UniProt Protein Name: | Microcephalin |
Protein Family: | Microcephalin |
UniProt Gene Name: | MCPH1 |
UniProt Entry Name: | MCPH1_HUMAN |