MCF2 Antibody, HRP conjugated (PACO63352)
- SKU:
- PACO63352
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | MCF2 Antibody, HRP conjugated (PACO63352) |
抗体コード: | PACO63352 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Proto-oncogene DBL protein (705-925AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42. |
シノニム: | Proto-oncogene DBL (Proto-oncogene MCF-2) [Cleaved into: MCF2-transforming protein; DBL-transforming protein], MCF2, DBL |
UniProt Protein Function: | MCF2: Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42. Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4- phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P). May interact with CCPG1. Isoform 1 is expressed only in brain. Isoform 3 is expressed in heart, kidney, spleen, liver and testis. Isoform 4 is expressed in brain, heart, kidney, testis, placenta, stomach and peripheral blood. The protein is detectable in brain, heart, kidney, intestine, muscle, lung and testis. Belongs to the MCF2 family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Apoptosis; Cell development/differentiation; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Chromosomal Location of Human Ortholog: Xq27.1 Cellular Component: cytoskeleton; cytosol Molecular Function:guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity Biological Process: positive regulation of apoptosis; regulation of small GTPase mediated signal transduction |
NCBI Summary: | The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.[provided by RefSeq, Jan 2010] |
UniProt Code: | P10911 |
NCBI GenInfo Identifier: | 92087039 |
NCBI Gene ID: | 4168 |
NCBI Accession: | P10911.3 |
UniProt Secondary Accession: | P10911,P14919, Q5JYJ2, Q5JYJ3, Q5JYJ4, Q8IUF3, Q8IUF4 B7Z3Y5, B7Z869, B7ZAV1, E9PH77, F5H091, |
UniProt Related Accession: | P10911 |
Molecular Weight: | 108kDa |
NCBI Full Name: | Proto-oncogene DBL |
NCBI Synonym Full Names: | MCF.2 cell line derived transforming sequence |
NCBI Official Symbol: | MCF2 |
NCBI Official Synonym Symbols: | DBL; ARHGEF21 |
NCBI Protein Information: | proto-oncogene DBL |
UniProt Protein Name: | Proto-oncogene DBL |
UniProt Synonym Protein Names: | Proto-oncogene MCF-2 |
Protein Family: | Proto-oncogene |
UniProt Gene Name: | MCF2 |