MCAM Antibody (PACO18721)
- SKU:
- PACO18721
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MCAM Antibody (PACO18721) |
抗体コード: | PACO18721 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
反応性: | Human |
免疫原: | Synthetic peptide of human MCAM |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human renal cancer tissue using PACO18721(MCAM Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human leiomyosarcoma tissue, Primary antibody: PACO18721(MCAM Antibody) at dilution 1/850, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18721(MCAM Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | CD146 (cluster of differentiation 146) also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. In humans, the CD146 protein is encoded by the MCAM gene. Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. |
シノニム: | melanoma cell adhesion molecule |
UniProt Protein Function: | MCAM: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: extracellular space; focal adhesion; integral to membrane; plasma membrane; nucleus; external side of plasma membrane Biological Process: anatomical structure morphogenesis; glomerular filtration; angiogenesis; cell adhesion; positive regulation of cell migration |
UniProt Code: | P43121 |
NCBI GenInfo Identifier: | 85681878 |
NCBI Gene ID: | 4162 |
NCBI Accession: | P43121.2 |
UniProt Secondary Accession: | P43121,O95812, Q59E86, Q6PHR3, Q6ZTR2, |
UniProt Related Accession: | P43121 |
Molecular Weight: | 646 |
NCBI Full Name: | Cell surface glycoprotein MUC18 |
NCBI Synonym Full Names: | melanoma cell adhesion molecule |
NCBI Official Symbol: | MCAM |
NCBI Official Synonym Symbols: | CD146; MUC18 |
NCBI Protein Information: | cell surface glycoprotein MUC18; Gicerin; melanoma adhesion molecule; cell surface glycoprotein P1H12; melanoma-associated antigen A32; melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen |
UniProt Protein Name: | Cell surface glycoprotein MUC18 |
UniProt Synonym Protein Names: | Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; CD_antigen: CD146 |
Protein Family: | Cell surface glycoprotein |
UniProt Gene Name: | MCAM |
UniProt Entry Name: | MUC18_HUMAN |
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