MC3R Antibody, FITC conjugated (PACO57854)
- SKU:
- PACO57854
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Description
抗体名: | MC3R Antibody, FITC conjugated (PACO57854) |
抗体コード: | PACO57854 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Melanocortin receptor 3 protein (38-74AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Receptor for MSH (alpha, β and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain. |
シノニム: | Melanocortin receptor 3 (MC3-R), MC3R |
UniProt Protein Function: | MC3R: Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1 Chromosomal Location of Human Ortholog: 20q13.2-q13.3 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:neuropeptide binding; protein binding; melanocortin receptor activity; peptide hormone binding; melanocyte stimulating hormone receptor activity Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to cyclic nucleotide second messenger; regulation of heart rate; homoiothermy; regulation of blood pressure; positive regulation of cAMP biosynthetic process; sodium ion homeostasis; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); circadian regulation of gene expression Disease: Body Mass Index Quantitative Trait Locus 9; Mycobacterium Tuberculosis, Susceptibility To |
NCBI Summary: | This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008] |
UniProt Code: | P41968 |
NCBI GenInfo Identifier: | 395398606 |
NCBI Gene ID: | 4159 |
NCBI Accession: | P41968.3 |
UniProt Related Accession: | P41968 |
Molecular Weight: | |
NCBI Full Name: | Melanocortin receptor 3 |
NCBI Synonym Full Names: | melanocortin 3 receptor |
NCBI Official Symbol: | MC3R |
NCBI Official Synonym Symbols: | MC3; OB20; OQTL; BMIQ9; MC3-R |
NCBI Protein Information: | melanocortin receptor 3 |
UniProt Protein Name: | Melanocortin receptor 3 |
Protein Family: | Melanocortin receptor |
UniProt Gene Name: | MC3R |
UniProt Entry Name: | MC3R_HUMAN |