MATK Antibody (PACO44391)
- SKU:
- PACO44391
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MATK Antibody (PACO44391) |
抗体コード: | PACO44391 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Megakaryocyte-associated tyrosine-protein kinase protein (393-507AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: MATK antibody at 5.06µg/ml. Lane 1: MCF-7 whole cell lysate. Lane 2: Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 57, 52 kDa. Observed band size: 52 kDa.. | |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO44391 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human brain tissue using PACO44391 at dilution of 1:100. |
バックグラウンド: | Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation. |
シノニム: | Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK), MATK, CTK HYL |
NCBI Summary: | The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P42679 |
NCBI GenInfo Identifier: | |
NCBI Gene ID: | 4145 |
NCBI Accession: | |
UniProt Related Accession: | P42679 |
Molecular Weight: | Observed MW: 56kDa |
NCBI Full Name: | |
NCBI Synonym Full Names: | megakaryocyte-associated tyrosine kinase |
NCBI Official Symbol: | MATK |
NCBI Official Synonym Symbols: | CHK; CTK; HYL; Lsk; HYLTK; HHYLTK |
NCBI Protein Information: | megakaryocyte-associated tyrosine-protein kinase |
UniProt Protein Name: | |
Protein Family: | Maturase |
UniProt Gene Name: |