| UniProt Protein Function: | MARCO: Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 2q14.2 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:pattern recognition receptor activity; transmembrane receptor activity Biological Process: cell surface receptor linked signal transduction; receptor-mediated endocytosis |
| NCBI Summary: | The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UEW3 |
| NCBI GenInfo Identifier: | 17380151 |
| NCBI Gene ID: | 8685 |
| NCBI Accession: | Q9UEW3.1 |
| UniProt Secondary Accession: | Q9UEW3,Q9Y5S3, B4DW79, |
| UniProt Related Accession: | Q9UEW3 |
| Molecular Weight: | 43,865 Da |
| NCBI Full Name: | Macrophage receptor MARCO |
| NCBI Synonym Full Names: | macrophage receptor with collagenous structure |
| NCBI Official Symbol: | MARCO |
| NCBI Official Synonym Symbols: | SCARA2 |
| NCBI Protein Information: | macrophage receptor MARCO |
| UniProt Protein Name: | Macrophage receptor MARCO |
| UniProt Synonym Protein Names: | Macrophage receptor with collagenous structure; Scavenger receptor class A member 2 |
| Protein Family: | Macrophage receptor |
| UniProt Gene Name: | MARCO |
| UniProt Entry Name: | MARCO_HUMAN |
